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Stanford University is committed to offer an equal employment opportunity and affirmative action employer. Every qualified candidate who meets the requirements of the position will be considered for employment without regard to race, color, gender identity, sex, religion, national origin, genetic information, age and disability. Stanford school of Medicine welcomes and encourages applications from diverse candidates. We strive to create a culture of inclusion and diversity by ensuring access to diversity fundings and outreach programs within the university and through external funding organizations. We are determined to reach a new level of instruction and innovation in research by attracting people with a variety of background and life experiences, which will provide a new vision to approach and conduct science. This effort is reflected in Stanford’s multiple diversity programs such as the Racial Equity to Advance a Community of Health (REACH) Initiative at Stanford Medicine, dedicated to train new generations of leaders in medicine and science who will actively promote health equity, racial equity, and social justice. 

Our mission at the Stanford School of Medicine is to provide a sustained leadership in cardiovascular research and personalized medicine. The Department grants an outstanding collaborative environment for scientist to advance their career and contribute substantially to the field in both basic and translational research. The Wu lab is part of the Cardiovascular Institute and combines drug discovery, bioengineering and disease modeling to achieve innovative projects in precision medicine.

We are seeking a highly skilled and talented senior scientist who specializes in cellular electrophysiology applied to cardiac disease. The candidate is expected to be experienced in both technical and theorical aspects of cardiac arrhythmias investigation and ion channels. Responsibilities of the position include:

• Design experiments to investigate the mechanism of electrical disturbances induced by genetic variants, drug administration or protocol optimization.
• Conducting cellular electrophysiology techniques: Patch clamp in current clamp and voltage clamp configuration on iPSC derived cardiomyocytes.
• Multielectrode array experiments with 2D and 3D models and EFP signal analysis.
• Data analysis and interpretation of action Potential and ion channel current recordings.
• Electrical stimulation protocol design and trouble shooting.
• Electrophysiology equipment maintenance and renewal.
• Establishing standardized protocols and solutions for current and action potential recordings and updating them.
  

Our laboratory provides a highly collaborative environment with opportunities to work on diversified and exciting projects and addressing relevant questions. The candidate will be responsible for accessing the study strategy to investigate arrhythmias observed in any given project and design the required experiments with data analysis workflow. The candidate will also train incoming postdocs and students to make basic measurements and consult on disease modeling projects. Furthermore, the selected candidate will be expected to provide finalized figures and participate in manuscript redaction when including electrophysiology results and revision follow ups.

The laboratory counts a full electrophysiology core with two patch clamp set-ups, Ion-optics device for intracellular calcium recordings and two multielectrode array devices. This equipment belongs to the laboratory, but we make it available to the Cardiovascular Institute laboratories along with the expertise of the electrophysiology postdoc/scientist, which provides a context of multiple collaboration and scientific exposure.

CORE DUTIES:

• Design and optimization of electrophysiology experiments and standardized protocols and solutions.
• Data analysis and interpretation.
• Equipment maintenance and updating.
• Manuscript writing and consulting on electrophysiology related projects.
• Model validation of arrhythmic-syndrome iPSC lines (CPVT, LQT).

*-Other duties may also be assigned.

We are seeking a candidate with a solid technical and scientific background in cellular electrophysiology and ion channels applied to cardiac disease.

The position qualifications include:

• The candidate will hold a Ph.D. in Physiology, Physics, Biophysics, or related disciplines with at least a 5-year postdoctoral or industry experience.
• Scientific programming and competency in software analysis of electrophysiology signals (Clampfit, Patch Master pro, R, Matlab, Axion Biosystem MEA software or equivalent).
• Induced Pluripotent Stem Cell culture (cell passaging, cardiac differentiation and cell replating)
• Ability to work independently and as a multidisciplinary team member.  
• Conducting cardiac electrophysiology investigations that will include setting up and performing experiments, analyzing data, as well as discussing, presenting and publishing scientific results.
• Training and providing standardized protocol for upcoming postdoctoral fellows or students who need to perform electrophysiology experiments.
• Being able to provide electrophysiology expertise to external collaborators within the Stanford CVI and outside the university.

Stanford is an equal employment opportunity and affirmative action employer.  All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stanford welcomes applications from all who would bring additional dimensions to the University's research mission.

The expected pay range for this position is $92,500 to $100,000 per annum.
Stanford University has provided a pay range representing its good faith estimate of what the university reasonably expects to pay for the position. The pay offered to the selected candidate will be determined based on factors including (but not limited to) the experience and qualifications of the selected candidate including equivalent years since their applicable education, field or discipline; departmental budget availability; internal equity; among other factors. 

As an organization that receives federal funding, Stanford University has a COVID-19 vaccination requirement that will apply to all university employees, including those working remotely in the United States and applicable subcontractors. To learn more about COVID policies and guidelines for Stanford University Staff, please visit https://cardinalatwork.stanford.edu/working-stanford/covid-19/interim-policies/covid-19-surveillance-testing-policy .